Fig. 2: GSH depletion induces oxidative stress and lipid peroxidation in RPE cells. | Cell Death & Disease

Fig. 2: GSH depletion induces oxidative stress and lipid peroxidation in RPE cells.

From: Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

Fig. 2

a Cytosolic ROS production assessed in ARPE-19 cells treated for 24 h with Cys2 starvation, 1000 µM BSO, and 10 µM erastin by flow cytometry using H2DCFDA. b Lipid ROS production assessed in ARPE-19 cells treated for 24 h with Cys2 starvation, 1000 µM BSO, and 10 µM erastin by flow cytometry using C11-BODIPY. c, d represent quantified data depicted in (a, b). Data in (c, d) represent mean ± SD from one of three representative experiments. Representative data from one of three experiments are shown. ** represent p < 0.01

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