Fig. 7: MiR-21 deficiency aggravated cardiac dysfunction post MI. | Cell Death & Disease

Fig. 7: MiR-21 deficiency aggravated cardiac dysfunction post MI.

From: MicroRNA-21 prevents excessive inflammation and cardiac dysfunction after myocardial infarction through targeting KBTBD7

Fig. 7

a MiR-21 WT or KO mice underwent baseline (BL) transthoracic echocardiographic examination. Mice were then subjected to MI or sham operation, or KO mice received MI were further injected with adenovirus expressing Kbtbd7 siRNA (KO-K7 si-MI) or control siRNA (KO-ctrl si-MI) into peri-infarct heart tissue. Mice were then followed with serial echocardiography at the indicated time points. LVEF, LVFS, LVIDd, LVIDs, LVEDV, and LVESV at different time points were shown. Data represent the mean ± SEM (n = 10 mice per group). *P < 0.05, **P < 0.01 WT-MI vs. KO-MI; #P < 0.05, ##P < 0.01 KO-K7 si-MI vs. KO-ctrl si-MI (two-way ANOVA). b Representative images were triphenyltetrazolium chloride (TTC)-stained heart sections from miR-21 WT or KO mice 1 week after treatment as in (a) showing infarct zone (white area). c, d Representative images of heart sections from miR-21 WT or KO mice stained with Masson trichrome at 4 weeks after treatment as in a, and scar circumference was measured and expressed as a percentage of total area of left-ventricular myocardium. Data represent the mean ± SEM (n = 10 mice per group). **P < 0.01 vs. WT-MI; ##P < 0.01 vs. KO-ctrl si-MI (two-way ANOVA)

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