Fig. 4: Role of ROS accumulation in chemoresistance of ESCC cells. | Cell Death & Disease

Fig. 4: Role of ROS accumulation in chemoresistance of ESCC cells.

From: Cisplatin-activated PAI-1 secretion in the cancer-associated fibroblasts with paracrine effects promoting esophageal squamous cell carcinoma progression and causing chemoresistance

Fig. 4: Role of ROS accumulation in chemoresistance of ESCC cells.

a–d ROS levels in KYSE-30 and KYSE-450 cells after 24 h of treatment with different concentrations of cisplatin. e, f PAI-1 pretreatment 2 h before cisplatin could inhibit ROS accumulation. The data are representative of experiments repeated three times, with similar results. The data are presented as the mean ± S.D. **p < 0.01, ***p < 0.001, vs the control group

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