Fig. 5: PEAK1 expression positively regulates ERK1/2 and JAK2 signaling, and induces the expression of Zeb2 or Twist2 in NSCLC cells. | Cell Death & Disease

Fig. 5: PEAK1 expression positively regulates ERK1/2 and JAK2 signaling, and induces the expression of Zeb2 or Twist2 in NSCLC cells.

From: Overexpression of PEAK1 contributes to epithelial–mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling

Fig. 5

a PEAK1 overexpression activated the ERK1/2 and JAK2 signaling pathways, but did not affect the activation of AKT, JNK, Rac1 or JAK1. b PEAK1 knockout inhibited ERK1/2 and JAK2 signaling activation. c Control (−) or PEAK1-overexpressing (+) 95D cell lysates were detected by IP with nontarget IgG (negative control), anti-ERK1/2 or anti-JAK2 antibody, and blotting for PEAK1 associated proteins. IP immunoprecipitation. d PEAK1 overexpression induced Zeb2 or Twist2 expression in different NSCLC cells. e PEAK1 knockout suppressed Zeb2 or Twist2 expression in different NSCLC cells

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