Fig. 2: miR-143 is necessary for granulocytic differentiation. | Cell Death & Disease

Fig. 2: miR-143 is necessary for granulocytic differentiation.

From: MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia

Fig. 2: miR-143 is necessary for granulocytic differentiation.

a, b FACS analysis of CD15 expression of G-CSF-treated CD34+ HSPCs (a) 7 days after stable overexpression (b) 11 days after stable knockdown of miR-143. c, d FACS analysis of CD11b expression at indicated time points in K562-C/EBPα-ER cells (c) after transient miR-143 overexpression or (d) stable miR-143 knockdown and treatment with β-estradiol. Numbers in dot blots indicate percentage of CD15+ or CD11b+ cells. Bars in diagrams represent the mean ± SD from three independent experiments. P values are relative to control. *P ≤ 0.05; **P ≤ 0.01, unpaired two-tailed t-tests

Back to article page