Fig. 3: Loss of neural progenitors caused by altered Sox2ot is due to early differentiation. | Cell Death & Disease

Fig. 3: Loss of neural progenitors caused by altered Sox2ot is due to early differentiation.

From: Long noncoding RNA Sox2ot and transcription factor YY1 co-regulate the differentiation of cortical neural progenitors by repressing Sox2

Fig. 3

a–d Electroporation of ectopic Sox2ot (OE) at E13.5 for analysis at E17.5 significantly increased the number of Tbr1+ or Satb2+ cells co-labeled with GFP in the cortex, compared to the control (Ctrl). e–h Electroporation of shRNAs against Sox2ot (shSox2ot A and shSox2ot B) at E13.5 for analysis at E17.5 significantly decreased the number of Tbr1+ or Satb2+ cells co-labeled with GFP in the cortex. Yellow and white cells indicate co-labeled cells. Data are presented as mean ± SD; n ≥ 5 sections from at least four different brains; p values in relation to the empty vector control (***p < 0.001). Scale bars: 50 µm

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