Fig. 7: YY1 knockdown increases neural progenitors.

a–h Electroporation of shRNAs against YY1 (shYY1 A and shYY1 B) at E13.5 for analysis at E14.5 significantly increased the number of BrdU-incorporating or Sox2⁺, Pax6⁺, or Tbr2⁺ cells co-labeled with GFP in the cortex, compared to the scrambled shRNA control (ShCtrl). i–l Electroporation of shRNAs against YY1 at E13.5 for analysis at E17.5 significantly decreased the number of Tbr1⁺ or Satb2⁺ cells co-labeled with GFP in the cortex. Yellow and white cells indicate co-labeled cells. Data are presented as mean±SD; n ≥ 5 sections from at least four different brains for all electroporations; p values in relation to the scrambled shRNA control (***p < 0.001). Scale bar=50 µm