Fig. 4: Differentially methylated loci in the DNA methylation profile and the pathway involved in cardiac muscle cell differentiation and development. | Cell Death & Disease

Fig. 4: Differentially methylated loci in the DNA methylation profile and the pathway involved in cardiac muscle cell differentiation and development.

From: The detrimental effects of glucocorticoids exposure during pregnancy on offspring’s cardiac functions mediated by hypermethylation of bone morphogenetic protein-4

Fig. 4

a The total mapped peaks and non-mapped peaks in NS and DEX group. b The total number of significantly (log2-fold change ≥ 2) increased and decreased methylated genes in prenatally DEX-exposed offspring compared with prenatally NS-exposed offspring. c, d The top 10 GO biological processes with increased methylation. (e, f) The top 10 GO biological processes with decreased methylation. g, h The fold enrichment of the pathways involved in cardiac muscle cell differentiation and development with increased methylation. i The heatmap presented the methylation levels of individual genes involved in cardiac muscle cell differentiation and development. Red: upregulation; green: downregulation

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