Fig. 5: HSV1 (FmutRHIM)-induced necroptosis requires ZBP1’s nucleic acid-binding domain as well as RHIM-A domain. | Cell Death & Disease

Fig. 5: HSV1 (FmutRHIM)-induced necroptosis requires ZBP1’s nucleic acid-binding domain as well as RHIM-A domain.

From: Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1

Fig. 5

a Schematic representation of the murine ZBP1 mutants. Red rectangle depicts Z-nucleic acid-binding domains, green rectangles represent RHIM-A and -B. Asterisk represents amino-acid mutation localized in Zα1, Zα2, RHIM-A, and RHIM-B. Numbers indicate amino-acid positions. Names of the mutants are listed on the left. b Cell viability of ZBP1-deficient SVEC4-10 cells reconstituted with indicated ZBP1 mutant constructs infected with HSV1 (FmutRHIM). c–e Kinetics of cell death of indicated ZBP1-reconstituted cell lines infected with HSV1 (FmutRHIM), measured in real time by Sytox green incorporation. See also Figure S3

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