Fig. 2: TRIM52-mediated regulation in ovarian cancer cells invasion, migration, proliferation, and apoptosis.
From: TRIM52 plays an oncogenic role in ovarian cancer associated with NF-kB pathway
Transwell experiments were employed to evaluate the effects of knockdown of TRIM52 in SKOV3/CAOV3 cells and overexpression of TRIM52 in HO8910 cells in ovarian cancer cell invasion (a–c) and migration (d–f). Annexin V-fluorescein isothiocyanate (FITC) and PI double-staining and Flow cytometry were performed to detect cell apoptosis in treated SKOV3/CAOV3 cells (g, h) and infected HO8910 cells (i). Cell Count Kit-8 (CCK-8) was used to assess cell proliferation. Optical density values (OD) at 24 h, 48 h, and 72 h after transfection were recorded in SKOV3/CAOV3 cells (j, k) and HO8910 cells (l). *P < 0.05, **P < 0.01, ***P < 0.001, versus NC or vector
