Fig. 5: NF-kB pathway involved TRIM52-mediated regulation in ovarian cancer cell invasion, migration, apoptosis, and proliferation.
From: TRIM52 plays an oncogenic role in ovarian cancer associated with NF-kB pathway
Transwell assays were employed to evaluate cells invasion and migration in SKOV3 cells treated with TRIM52-Ri3 plus LPS (a, c) and in HO8910 cells treated with TRIM52 lentivirus plus PDTC (b, d). Cell apoptosis were assessed by Annexin V-fluorescein isothiocyanate (FITC) and PI double-staining and flow cytometry in SKOV3 cells treated with TRIM52-Ri3 plus LPS (e) and in HO8910 cells treated with TRIM52 lentivirus plus PDTC (f). CCK-8 experiments were used to evaluate cell proliferation in SKOV3 cells treated with TRIM52-Ri3 plus LPS (g) and in HO8910 cells treated with TRIM52 lentivirus plus PDTC (h). *P < 0.05, **P < 0.01, ***P < 0.001, (g: TRIM52-Ri3 versus TRIM52-Ri3 + LPS; h: TRIM52 versus TRIM52 + PDTC)
