Fig. 1: Effect of BBR on hepatic cholesterol accumulation and blockade of autophagic flux. | Cell Death & Disease

Fig. 1: Effect of BBR on hepatic cholesterol accumulation and blockade of autophagic flux.

From: Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis

Fig. 1

a, b Cholesterol levels in the livers from mice fed with atherogenic diet (AD) or chow diet and treated with berberine (BBR) or ezetimibe (Eze). *p < 0.05 and **p < 0.01 when compared with chow diet; #p < 0.05 and ##p < 0.01 when compared with AD. c H&E staining of liver tissues from each group (magnification: ×40). d, e LC3B-II and p62 protein levels in livers from mice fed with chow diet, AD, or treated with BBR or Eze. *p < 0.05 and **p < 0.01 when compared with chow diet; #p < 0.05 and ##p < 0.01 when compared with AD. f Hepatic LC3B-II and p62 protein levels between patients with high cholesterol level (HC) and those with low cholesterol level (LC) in their livers. **p < 0.01 for the HC group compared with the LC group

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