Table 3 Cox regression analysis of risk factors for cancer-related death in lung cancer patients

Characteristics	Univariate analysis		Multivariate analysis
Characteristics	HR^a (95% CI^b)	P-value^c	HR^a (95% CI^b)	P-value^c
Rab37/SFRP1/Oct4 protein expression^d
+/+/−	1.00		1.00
Others	1.87 (0.82–4.26)	0.137	2.13 (0.92–4.96)	0.079
−/−/+	4.28 (1.79–10.3)	0.001	3.09 (1.24–7.74)	0.016
Age
<65 year-old	1.00		–^f
≥65 year-old	1.35 (0.78–2.32)	0.282	–^f	–^f
Gender
Female	1.00		–^f
Male	1.73 (1.00–3.01)	0.052	–^f	–^f
Smoking habit
Non-smoker	1.00		–^f
Smoker	1.57 (0.91–2.70)	0.102	–^f	–^f
Type^e
SCC	1.00		–^f
ADC	0.98 (0.48–2.01)	0.947	–^f	–^f
Stage
Stage I-II	1.00		1.00
Stage III-IV	2.74 (1.59–4.74)	<0.001	0.70 (0.32–1.54)	0.378
T stage
Stage 1–2	1.00		1.00
Stage 3–4	2.28 (1.03–5.07)	0.043	1.39 (0.58–3.34)	0.459
N stage
N0	1.00		1.00
≥N1	3.72 (2.18–6.34)	<0.001	3.79 (1.98–7.28)	<0.001
M stage
M0	1.00		1.00
≥M1	3.94 (1.88–8.28)	<0.001	2.98 (1.20–7.41)	0.019

^aHR hazard ratio
^bCI confidence interval
^cBold values indicate statistical significance (P < 0.05)
^dPatients were grouped according to Rab37, SFRP1 and Oct4 expression, respectively. +: preserved; −: low expression for Rab37 and SFRP1; +: high; −: normal expression for Oct4
^eADC adenocarcinoma, SCC squamous-cell carcinoma
^fData were not included in multivariate

Quick links

Search