Fig. 4: MRE11 depletion induces DDR and cell death and impairs mirin effects on MYCN+ cells.
From: MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors
a, b MYCN + SHEP Tet21/N cells were transfected with no-target or MRE11-directed stealth RNAi. Cell death (upper panel) and DDR (bottom panel) were measured by the trypan blue exclusion assay and WB analysis of the indicated proteins and phosphoepitopes, respectively, after 24 h of transfection. Average data obtained by three independent cell death assays are reported as fold induction compared to untreated controls, ±SD. p was calculated by the Student’s t-test. *p < 0.05. b After MRE11 knockdown, the effects of mirin were assessed as above. p was calculated by the ANOVA test. **p < 0.01
