Fig. 3: HDAC6 inhibitor TST repressed RTK expression. | Cell Death & Disease

Fig. 3: HDAC6 inhibitor TST repressed RTK expression.

From: HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation

Fig. 3

a T47D and b BT474 cells were treated with different concentrations of TST for 24 h. Western blot analyses were performed to detect α-tubulin and its acetylation level. c T47D and d BT474 cells were exposed to increasing doses of TST for 24 h. Cell viability was evaluated by MTT assay. e T47D cells were treated with 10 μM TST and f BT474 cells were treated with 15 μM TST for indicated times. Indicated proteins were detected by western blot. g, h PI3K/AKT/mTOR signaling and acetylation of α-tubulin were detected under the same treatment in T47D and BT474 cells. *P < 0.05, **P < 0.01, and ***P < 0.001 versus control group. Data shown are mean ± SEM of at least three independent experiments

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