Fig. 6: DNA repair is inhibited by Stat3 inhibition. | Cell Death & Disease

Fig. 6: DNA repair is inhibited by Stat3 inhibition.

From: MSCs inhibit tumor progression and enhance radiosensitivity of breast cancer cells by down-regulating Stat3 signaling pathway

Fig. 6

MSC-CM and the MSC-CM combination with radiation increased p-BRCA1, 53BP1, p-ATM, p-p53 and p-CHK1expression. Cells were treated with MSC-CM or treated with ionizing radiation. Six hours after ionizing radiation, cells were harvested, and the cell lysates were analysed by immunoblotting using the indicated antibodies. *P < 0.05 vs Ctrl, **P < 0.01 vs Ctrl, ***P < 0.001 vs Ctrl, #P < 0.05 vs MSC-CM, ##P < 0.01 vs MSC-CM, ###P < 0.001 vs MSC-CM, $$ P < 0.01 vs 4 Gy, $$$P < 0.001 vs 4 Gy, n = 3

Back to article page