Fig. 5: Res-hucMSCs promoted angiogenesis via paracrine PDGF-DD. | Cell Death & Disease

Fig. 5: Res-hucMSCs promoted angiogenesis via paracrine PDGF-DD.

From: Resveratrol improves human umbilical cord-derived mesenchymal stem cells repair for cisplatin-induced acute kidney injury

Fig. 5

a The CdM of Res-hucMSCs promoted migration of HUVEC cells compared with the CdM of DMSO-hucMSCs (*P < 0.05). b Cell-counting assay for the proliferation of HUVEC cells (*P < 0.05 and **P < 0.01). c HUVEC cells proliferation was measured using a real-time cellular analysis (RTCA) system. d Representative immunofluorescence images of CD31 expression in injured kidney tissues after different treatment (magnification × 200, Scale bars = 50 μm). e The migration ability of HUVEC cells treated with the CdM of Res-hucMSCs with or without PDGF-DD siRNA treatment. f The statistical figure of migratory HUVEC cells (**P < 0.01 and ***P < 0.001). g Cell-counting assay for the proliferation of HUVEC cells treated with the CdM of Res-hucMSCs with or without PDGF-DD siRNA treatment (*P < 0.05 and **P < 0.01). h The cisplatin-induced kidney injury models were treated with Res-hucMSCs with or without PDGF-DD siRNA treatment for 4 days. The expression of CD31 in the injured kidney area was measured using immunofluorescence staining (magnification × 200, Scale bars = 50 μm)

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