Fig. 9: Ki8751 could suppress CRC progression through EMT process and inactivating Akt/mTOR signaling pathway. | Cell Death & Disease

Fig. 9: Ki8751 could suppress CRC progression through EMT process and inactivating Akt/mTOR signaling pathway.

From: SP1-induced lncRNA-ZFAS1 contributes to colorectal cancer progression via the miR-150-5p/VEGFA axis

Fig. 9: Ki8751 could suppress CRC progression through EMT process and inactivating Akt/mTOR signaling pathway.The alt text for this image may have been generated using AI.

a Western blot was performed to detect the expression of VEGFR2, p-VEGFR2, Akt, p-Akt, mTOR, p-mTOR, E-cadherin, Vimentin, and N-cadherin after adding Ki8751 to HCT116, and HCT8 cells. b–d Ki8751 inhibited proliferation (b), migration (c), and invasion (d) of HCT116 and HCT8 cells, and suppressed HUVECs tube formation (e). Results are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001

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