Table 1 ITC affinity measurements of NRZ: BH3 motif interactions
From: A structural investigation of NRZ mediated apoptosis regulation in zebrafish
Peptide | WT NRZ KD (nM) | NRZ R86A KD (nM) | NRZ D79A KD (nM) |
|---|---|---|---|
Bax | 688 ± 111 | 4600 ± 440 | 264 ± 42 |
Bim | 41 ± 5 | 168 ± 8 | 13 ± 4 |
Bad | 343 ± 48 | 4800 ± 88 | 3330 ± 41 |
Puma | 36 ± 4 | 2770 ± 162 | 117 ± 5 |
Bik | 12 ± 2 | 17 ± 3 | 14 ± 3 |
Noxa | 142 ± 16 | 510 ± 41 | 335 ± 31 |
Bcl-wav | 3570 ± 162 | NB | NB |
Bid | 409 ± 55 | NB | 220 ± 16 |
Bmf | NB | NB | NB |
Beclin | NB | NB | NB |
