Fig. 1: Osteoarthritic changes in knee joints and autophagy marker expression. | Cell Death & Disease

Fig. 1: Osteoarthritic changes in knee joints and autophagy marker expression.

From: MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12

Fig. 1

a Histological evidence of articular cartilage degeneration in Safranin-O stained ACLT-affected joints, as compared to sham surgery controls. Mankin score and OARSI score were significantly increased at 8 weeks postoperatively. b Decreased expressions of Atg4, Atg12, p62, and Beclin along with c reduced LC3-II levels in ACLT-affected articular cartilage. d Few chondrocytes in ACLT-injured joints showed Atg12 and LC3 immunostaining. Data per group are expressed as mean ± SEM calculated from eight rats. Asterisks (*) indicate P < 0.05 between groups

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