Fig. 6: Effects of miR-128a signaling on apoptosis and cartilage formation in vitro. | Cell Death & Disease

Fig. 6: Effects of miR-128a signaling on apoptosis and cartilage formation in vitro.

From: MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12

Fig. 6

Forced miR-128a expression a increased miR-128a expression and levels of Bax, Bcl2, cleaved caspase-3, and b apoptosis in chondrocytic cells. c A large number of miR-128a precursor-treated chondrocytes displaying strong TUNEL staining. d Reduced cartilage ECM synthesis and expressions of SOX9, collagen II, and aggrecan upon miR-128a expression in chondrocyte micro-mass cultures. Note the reduced apoptosis and TUNEL staining upon knockdown of miR-128a, with enhanced cartilage formation by chondrocytes. Data are expressed as the means ± SEM calculated from six repeated experiments. Asterisks (*) indicate P < 0.05 between groups

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