Fig. 2: Relationship between PHGDH and stemness-regulating factors is reflected in human tumors, and is indicative for patient prognosis. | Cell Death & Disease

Fig. 2: Relationship between PHGDH and stemness-regulating factors is reflected in human tumors, and is indicative for patient prognosis.

From: Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells

Fig. 2

a GSE25066 database from breast tumors was analyzed for the correlation between PHGDH and OCT4, MYC, SOX9, and CD133. b Kaplan Meier survival analysis of public patient biopsy datasets based on high expression of both PHGDH and OCT4 (Double High) versus low expression of both PHGDH and OCT4 (Double Low) (cutoff = median expression) from breast tumors (GSE25066). c Kaplan Meier survival analysis of public patient biopsy datasets based on high expression of both PHGDH and SOX9 (Double High) versus low expression of both PHGDH and SOX9 (Double Low) (cutoff = median expression) from breast tumors (GSE25066)

Back to article page