Fig. 2: UPR preconditioning ablates NF-κB activation in the hTERT-HM uterine myocyte. | Cell Death & Disease

Fig. 2: UPR preconditioning ablates NF-κB activation in the hTERT-HM uterine myocyte.

From: Preconditioning the uterine unfolded protein response maintains non-apoptotic Caspase 3-dependent quiescence during pregnancy

Fig. 2

a, b, d, e Activation of NF-κB was significantly increased in both TM and Thaps non-preconditioned (NP) cells and reduced to barely detectable levels in preconditioned (P) cells 2 h post administration of a cytotoxic dose of TM/Thaps. c, f TNFα secretion was also reduced in P versus NP cells. A representative blot from each experiment is shown. NCOA3 is utilized as nuclear protein loading control. Statistical comparisons were performed using one-way ANOVA, and subsequent Newman–Keuls multiple-comparison tests. Data labeled with different letters are significantly different from each other (p < 0.05)

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