Fig. 6: Preconditioning facilitates the suppression of prostaglandin synthesis thereby preventing premature luteolysis and P4 withdrawal. | Cell Death & Disease

Fig. 6: Preconditioning facilitates the suppression of prostaglandin synthesis thereby preventing premature luteolysis and P4 withdrawal.

From: Preconditioning the uterine unfolded protein response maintains non-apoptotic Caspase 3-dependent quiescence during pregnancy

Fig. 6

Uteri collected from vehicle treated (Con), sub-preconditioned (PBA), exogenously stressed-sub-preconditioned (TM+PBA) and exogenously stressed-preconditioned (TM) mice on E17 prior to the onset of preterm and term birth, were examined for prostaglandin production. Significantly elevated levels of a PGE1, b PGE2, and d PGD3 were isolated to TM+PBA uteri. e Ovarian HSD3B2 and f serum P4 levels were significantly decreased in the TM+PBA-treated mice. A representative blot from each experiment is shown. PDIA2 is utilized as cytoplasmic protein loading control. Statistical comparisons were performed using one-way ANOVA, subsequent Newman–Keuls multiple-comparison tests and Student's t-test. *p ≤ 0.05 and **p ≤ 0.01 compared with controls

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