Fig. 4: PLK-4 expression is positive associated with poor prognosis of HCC. | Cell Death & Disease

Fig. 4: PLK-4 expression is positive associated with poor prognosis of HCC.

From: MiR-126 negatively regulates PLK-4 to impact the development of hepatocellular carcinoma via ATR/CHEK1 pathway

Fig. 4: PLK-4 expression is positive associated with poor prognosis of HCC.

a, b PLK-4 expression was significantly increased in HCC tissues compared with non-tumor tissues by IHC assay and based on PLK4 staining score, the PLK4 expression was analyzed in HCC tissues compared with that in non-tumor tissues. Scale bars = 100 μm. c Representative pictures of PLK-4 expression in HCC tissues. Scale bars = 500 μm. d The detailed staining scores of PLK-4 in TNM stage, vascular invasion, liver cirrhosis and tumor size. e Univaraite analysis between clinicopathologic features and OS in HCC patients. Mean ± SD, *P < 0.05, **P < 0.01, unpaired Student’s t test or one-way ANNOVA followed by multiple t test. f OS analysis of the patients based on PLK-4 expression in ZZU cohort 2. Mean ± SD, unpaired Student’s t test or Kaplan–Meier analysis

Back to article page