Cell Death & Disease

Table 3 Univariate analysis for disease-free survival (DFS) and overall survival (OS)

From: Keratin 80 promotes migration and invasion of colorectal carcinoma by interacting with PRKDC via activating the AKT pathway

Variable	DFS			OS
Variable	HR	95% CI	P value	HR	95% CI	P value
Age, years
< 65	—			—
≥ 65	0.962	0.605–1.530	0.870	1.071	0.648–1.772	0.788
Gender
Male	—			—
Female	0.872	0.543–1.399	0.570	1.140	0.685–1.897	0.614
Location
Ascending	—			—
Transverse	1.297	0.622–2.705	0.487	1.438	0.655–3.158	0.365
Descending	1.978	0.786–4.979	0.148	2.340	0.909–6.022	0.078
Sigmoid	1.301	0.570–2.973	0.532	0.730	0.244–2.186	0.574
Rectum	1.112	0.627–1.973	0.717	1.284	0.695–2.372	0.424
T stage
T1+T2	—			—
T3+T4	2.057	1.251–3.381	0.004^a	2.200	1.281–3.777	0.004^a
N stage
N0	—			—
N1	2.154	1.353–3.429	0.001^a	2.474	1.497–4.087	< 0.001^a
M stage
M0	—			—
M1	3.262	1.891–5.629	< 0.001^a	4.000	2.281–7.014	< 0.001^a
AJCC stage
I + II	—			—
III + IV	2.451	1.519–3.956	< 0.001^a	2.580	1.536–4.334	< 0.001^a
Differentiation
Well	—			—
Moderate	2.278	1.238–4.192	0.008^a	2.486	1.274–4.852	0.008^a
Poor	3.560	1.865–6.797	< 0.001^a	3.700	1.833–7.468	< 0.001^a
Vessel invasion
No	—			—
Yes	2.067	1.197–3.568	0.009^a	2.166	1.208–3.884	0.010^a
KRT80 expression
Negative	—			—
Positive	3.897	2.213–6.864	< 0.001^a	3.397	1.882–6.132	< 0.001^a

HR hazard ratio, CI confidence interval
^aP < 0.05 was considered significant

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