Fig. 6: Iron supplementation reverses the HIF1α-stabilizing and DNA damage-inducing activities of PAC-1. | Cell Death & Disease

Fig. 6: Iron supplementation reverses the HIF1α-stabilizing and DNA damage-inducing activities of PAC-1.

From: Procaspase-3-activating compound 1 stabilizes hypoxia-inducible factor 1α and induces DNA damage by sequestering ferrous iron

Fig. 6

a, b HIF1α stabilization status in HIF1α-EGFP_CHO cells after 3 h of treatment (PAC-1 concentration: 30 μM). c, d RAD51 and pH2AX levels in RAD51-EGFP_SW480 cells after 24 h of treatment with 30 μM PAC-1 with or without FeCl2 supplementation. e Cell cycle distribution status in HepG2 cells after the indicated treatments for 24 h. Data represent means ± SEs of three independent experiments

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