Fig. 4: Combining pharmacological inhibition of NHE1 enhances TMZ therapy in inducing apoptosis and blockade of glioma growth. | Cell Death & Disease

Fig. 4: Combining pharmacological inhibition of NHE1 enhances TMZ therapy in inducing apoptosis and blockade of glioma growth.

From: Blockade of Na/H exchanger stimulates glioma tumor immunogenicity and enhances combinatorial TMZ and anti-PD-1 therapy

Fig. 4

a Combination treatments reduced SB28-GFP tumor volume at 7 d.p.i. in the same cohort of mice described in Fig. 1e. Data are means ± SD (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001. b Ki67-positive proliferating cell counts in GBM tumors. Data are means ± SEM (n = 5). *p < 0.05, ***p < 0.001. c Cleaved caspase-3-positive apoptotic cell counts in GBM tumors. Data are means ± SEM (n = 5). **p < 0.01, ***p < 0.001

Back to article page