Fig. 2: Spontaneous gait abnormality of HIP2+/− mice. | Cell Death & Disease

Fig. 2: Spontaneous gait abnormality of HIP2+/− mice.

From: Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson’s disease models

Fig. 2: Spontaneous gait abnormality of HIP2+/− mice.The alternative text for this image may have been generated using AI.

a Schematic representation of the definition for stride length ①, fore-stride width ②, hind-stride width ③, and forepaw–hindpaw distance ④ measurement. The details are described in “Materials and methods”. b HIP2+/− mice showed significant shorter distance in stride length at the age of 15 months (P = 0.0272) and 18 months (P = 0.0001). c, d HIP2+/− mice had broader fore-stride width (c, P values for mice with indicated ages are: 0.0038 (9 months), 0.0297 (12 months), 0.0023 (15 months), 0.014 (18 months)) and hind-stride width (d, P values are: 0.0012 (9 months), 0.0006 (12 months), <0.0001 (15 months), 0.0002 (18 months)) at all ages than WT mice. e HIP2+/− mice showed significant difference in fore–hind paws distance at all ages (P values: 0.0257 (9 months), 0.0016 (12 months), 0.0031 (15 months), 0.0003 (18 months)). The number of animals in each group is listed in “Materials and methods”. All P values in this figure were analyzed by unpaired t-test

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