Fig. 3: Spontaneous motor deficits occurred in HIP2+/− mice at 9-month age. | Cell Death & Disease

Fig. 3: Spontaneous motor deficits occurred in HIP2+/− mice at 9-month age.

From: Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson’s disease models

Fig. 3: Spontaneous motor deficits occurred in HIP2+/− mice at 9-month age.The alternative text for this image may have been generated using AI.

a–c The latency of mice crossing beams 1–5 of narrowing width in beam walking test. On days 1 (a, P = 0.0307) and 3 (c, P = 0.0179), there were statistically significant difference in the latency between the WT and HIP2+/− mice. d–f The number of slip-offs from the beams for mice crossing the beams. Note that the HIP2+/− mice slipped more frequently when crossing beams in all 3 days (d, P = 0.0009; e, P = 0.0017; f, P < 0.0001). g, h HIP2+/− mice showed longer latency for crossing beam 4 (P = 0.0003) and more slips crossing beam 5 (P = 0.0108) in all 3 days. The gradually increased latency and number of slip-offs for mice on different beams were caused by different task difficulties (P < 0.0001 in all 3 days). All P values of beam walking test results were analyzed by two-way ANOVA followed by Bonferroni’s post-hoc test. i Rotarod test showing the shorter latency for HIP2+/− mice before falling off than for the WT mice (P < 0.0001 by unpaired t-test). N = 9 mice for WT and 12 mice for HIP2+/−

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