Fig. 2: MINA53 regulates the CMG complex genes expression. | Cell Death & Disease

Fig. 2: MINA53 regulates the CMG complex genes expression.

From: MINA53 deficiency leads to glioblastoma cell apoptosis via inducing DNA replication stress and diminishing DNA damage response

Fig. 2

a Expression alteration of CMG genes in LN-229 cells after MINA53 knockdown for 3 or 5 days. b mRNA expression of the indicated genes in LN-229 and c U-87 MG cells with or without MINA53 knockdown. d ChIP-qPCR analysis of MINA53 enrichment at the promoter regions of CDC45, MCM2, MCM3, or MCM5 in LN-229 cells. e ChIP-qPCR analysis of H3K9me3 enrichment at the promoter regions of CDC45, MCM2, MCM3, or MCM5 in LN-229 cells with or without MINA53 knockdown. All data were analyzed using two-tailed Student’s t-tests. Mean ± s.e.m., n = 3, *P < 0.05, **P < 0.01, ***P < 0.001

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