Fig. 5: MINA53 deficiency sensitizes glioblastoma cells to Doxorubicin. | Cell Death & Disease

Fig. 5: MINA53 deficiency sensitizes glioblastoma cells to Doxorubicin.

From: MINA53 deficiency leads to glioblastoma cell apoptosis via inducing DNA replication stress and diminishing DNA damage response

Fig. 5

U-87 MG cells with or without MINA53 knockdown were stimulated with Doxorubicin at indicated concentrations for 24 or 48 h. a Quantification of the percentage of dead cells and b the percentage of tail DNA in the indicated cells. c Western blot analysis of the indicated proteins after U-87 MG cells with or without MINA53 knockdown were stimulated with Doxorubicin at the indicated concentrations for 48 h. d Flow cytometry assays analyzing cell apoptosis and e quantification of the percentage of apoptosis cells of U-87 MG cells with or without MINA53 knockdown after stimulated with 500 nM Doxorubicin for 48 h. All data were analyzed using two-tailed Student’s t-tests. Mean ± s.e.m., n = 3, ***P < 0.001

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