Fig. 4: TRAF4 expression is associated with glioma grade, miR-29a/b/c levels and patient prognoses.
From: miR-29s function as tumor suppressors in gliomas by targeting TRAF4 and predict patient prognosis
a Representative images of TRAF4 immunohistochemistry. Scale bar: 50 μm. b Comparisons of the TRAF4 expression level [labeling index, LI (%)] among the control and the glioma groups. The LI (%) was calculated as described in Fig. 1, and the data are presented as the mean ± SD. ***P < 0.001. c The LI of TRAF4 was inversely correlated with the LIs of miR-29a/b/c as shown by Pearson analyses. d–g Kaplan–Meier survival analyses of the associations between the TRAF4 level and the DFS (left) or OS (right) of the patients. The analyses were conducted in the cohort of all glioma patients (d), patients with grade IV gliomas (e), patients with IDH1 R132H mutant gliomas (f), and patients with IDH1/2 wild-type gliomas (g). Patients were stratified into high and low expression subgroups using the medians of the TRAF4 LI of the corresponding cohort
