Fig. 1: Activity of Triapine and its derivative Me2NNMe2. | Cell Death & Disease

Fig. 1: Activity of Triapine and its derivative Me2NNMe2.

From: The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition

Fig. 1: Activity of Triapine and its derivative Me2NNMe2.The alt text for this image may have been generated using AI.

a Time-dependent cell viability of SW480 and HCT-116 cells treated with either Triapine or Me2NNMe2, determined by MTT assay after 24, 48, and 72 h. Values given in the graph are the mean ± standard deviation of triplicates from one representative experiment out of three, normalized to the untreated control of the same time-point. IC50 values (µM) ± standard deviations (SD) are given in the table . b Morphological changes in SW480 cells induced by 24 and 48 h treatment with the indicated concentrations of Triapine or Me2NNMe2. Cytoplasmic vacuoles were mainly seen with Me2NNMe2 (arrows). Scale bar: 100 µm. c Increase in cell size of SW480 and HCT-116 cells treated with the indicated concentrations of Triapine and Me2NNMe2 for 48 h

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