Table 2 Univariate and multivariate analysis for OS of CRC patients

From: DNA-methylation-mediated silencing of miR-486-5p promotes colorectal cancer proliferation and migration through activation of PLAGL2/IGF2/β-catenin signal pathways

Variables

Univariate analysis

Multivariate analysis

 

HR

95% CI

p Value

HR

95% CI

p Value

Gender (male, female)

2.599

0.838–8.066

0.089

   

Age (>63, ≤63), years

0.762

0.277–2.098

0.599

   

Tumor location (colon, rectum)

0.598

0.224–1.598

0.306

   

TNM stage (III+IV, I+II)

4.44

1.42–13.89

0.01

3.87

1.13–13.33

0.031

Histologic grade (3, 1+2)

4.67

1.06–20.4

0.042

5.35

1.09–26.32

0.038

Lymphatic metastasis (N1+N2, N0)

2.81

1.04–7.58

0.041

1.93

0.65–5.68

0.235

Distant metastasis (M1, M0)

5.92

1.99–17.54

0.001

2.78

0.76–10.1

0.121

Tumor size (>4 cm, ≤4 cm)

4.062

0.92–17.94

0.064

4.51

0.89–22.67

0.067

miR-486-5p expression (high, low)

0.306

0.11–0.83

0.019

0.68

0.21–2.22

0.523

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