Fig. 1: The expression of RACK1 in human colonic epithelial carcinogenic process and colon cancer cell lines and association of RACK1 expression levels with the patient prognosis.
From: RACK1 promotes tumorigenicity of colon cancer by inducing cell autophagy
a A representative result of immunohistochemistry showing the expression of RACK1 in the normal colonic mucosa (NCM), polyp, adenoma, adenocarcinoma, and lymph node metastasis (LNM). Scale bars = 100 μm. b Statistical analysis of RACK1 expression in the carcinogenic process of colonic epithelium. *P < 0.01; **P < 0.01; ***P < 0.001. c Kaplan–Meier survival analysis for 180 colon cancer patients according to the expression levels of RACK. Patients with high RACK1 expression have a significantly worse overall survival than those with low RACK1 expression. The log-rank test was used to calculate P-value. d Western blot analysis showing RACK1 levels in the five colon cancer cell lines (HT-29, SW480, SW620, HCT116, and HRT18) and four fresh normal colonic mucosae (NCM)
