Fig. 8: The expression of key molecules involved in autophagy and apoptosis during sequential progression of oral carcinogenesis (mean ± SD; n = 3). | Cell Death & Disease

Fig. 8: The expression of key molecules involved in autophagy and apoptosis during sequential progression of oral carcinogenesis (mean ± SD; n = 3).

From: Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer

Fig. 8

a Immunoblotting was performed to analyse the expression of ATG5, Beclin, LC-3, Bax, Bcl-2, and Cleaved caspase-3 during sequential progression of HBP carcinomas. β-actin was used as loading control. b Representative photomicrographs of immunohistochemical staining of LC-3 during sequential progression of HBP carcinomas (×40). c Representative photomicrographs of immunohistochemical staining of LC-3, Bax, Bcl-2, and p-AktSer473 in control and different histological grades of human oral cancer tissues (×40). 0 w, 0 week; 4 w, 4 weeks; 8 w, 8 weeks; 12 w, 12 weeks; 16 w, 16 weeks

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