Table 1 Peptide design and IC50 values of DTT peptides against various cell lines
From: Oncolysis with DTT-205 and DTT-304 generates immunological memory in cured animals
Compound | JM1 | BEL-7402 | HEPG2 | HepaRG | CT-26 | HT-29 | CC531 | MRC-5 | HUVEC | hRBCs |
|---|---|---|---|---|---|---|---|---|---|---|
DTT-106 | 17.5 ± 4.2 | 27.1 ± 0.5 | 27.05 ± 0.6 | 24.1 | 9.7 ± 0.4 | 25.8 ± 1.2 | 26.7 ± 4.3 | 28.6 ± 2.4 | 29.3 ± 0.2 | ND |
DTT-201 | 26 ± 3.0 | > 31 | > 31 | ND | 10.8 ± 1.3 | > 31 | > 31 | > 31 | > 31 | ND |
DTT-202 | 15.9 ± 2.3 | > 31 | > 31 | 23.3 ± 0.9 | 7.4 ± 1.6 | 23.4 ± 0.5 | 16.5 ± 1.4 | 23.3 ± 2.2 | 29.9 ± 1.2 | ND |
DTT-203 | 13.4 ± 5.9 | 19.0 ± 1.3 | 23.4 ± 3.1 | 22.6 | 8.1 ± 0.6 | 26.5 ± 0.9 | > 31 | 30.5 ± 1.7 | 29.5 ± 0.8 | ND |
DTT-204 | 16.4 ± 1.0 | 22.9 ± 0.8 | > 31 | ND | 8.1 ± 1.2 | 16.5 ± 3.4 | 25.2 ± 0.4 | 24.0 ± 3.0 | 27.5 ± 2.5 | ND |
DTT-205 | 6.9 ± 1.7 | 10.3 ± 0.3 | 23.6 ± 0.7 | 9.0 ± 0.3 | 8.2 ± 0.5 | 9.8 ± 0.9 | 13.0 ± 0.3 | 11.2 ± 0.1 | 10.6 ± 2.6 | 526–614 |
DTT-122 | > 31 | > 31 | > 31 | ND | ND | > 31 | ND | ND | ND | ND |
DTT-301 | 26.0 ± 2.9 | > 31 | > 31 | ND | 6.7 ± 0.6 | > 31 | > 31 | > 31 | > 31 | ND |
DTT-302 | 16.3 ± 1.2 | > 31 | 24.5 ± 3.4 | 21.1 | 10.1 ± 1.5 | > 31 | > 31 | > 31 | > 31 | ND |
DTT-303 | 13.0 ± 0.8 | 19.5 ±2.4 | 20.2 ± 3.6 | 28.5 | 6.0 ± 0.5 | > 31 | 25.8 ± 5.8 | 26.7 ± 3.4 | > 31 | ND |
DTT-304 | 13.0 ± 1.3 | 16.4 ± 0.2 | 21.4 ± 0.3 | 15.0 ± 2.1 | 8.6 ± 2.6 | 21.1 ± 1.7 | 24.3 ± 6.7 | 29.0 ± 2.0 | 27.9 ± 2.1 | > 928 |
DTT-305 | 12.4 ± 2.0 | 15.8 ± 0.05 | 20.6 ± 2.4 | 14.8 ± 0.4 | 7.8 ± 2.0 | 9.0 ± 0.8 | 15.7 ± 0.3 | 12.4 ± 0.2 | 15.0 ± 0.3 | ND |
DTT-306 | 8.7 ± 0.7 | 11.6 ± 0.5 | 20.1 ± 2.8 | 12.5 | 7.5 ± 1.7 | 4.7 ± 0.9 | 13.1 ± 2.1 | 17.5 ± 2.3 | 16.4 ± 1.5 | ND |
