Fig. 7: The impact of chloroquine pretreatment on biomarkers of the MAPK family, NF-κB pathway, autophagy, and apoptosis following CCl4- induced acute liver injury in mice. | Cell Death & Disease

Fig. 7: The impact of chloroquine pretreatment on biomarkers of the MAPK family, NF-κB pathway, autophagy, and apoptosis following CCl4- induced acute liver injury in mice.

From: Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis

Fig. 7

a Western blot analysis for LC3, Beclin1, phosphorylation (p)-Erk, p- JNK, p-p38, p53, Bax, Bcl-2, NF-κB, IκBa, and cleaved caspase-3 were performed on the liver tissue of mice at 2, 6, 12, 24, and 48 h from the CCl4 + vehicle and CCl4 + chloroquine (CQ) groups (n = 3). b The densitometric analysis of the bands was conducted using Image J. Data are shown as mean ± SD (n = 3). *P < 0.05 and **P < 0.01, compared with the control group; #P < 0.05 and ##P < 0.01, compared with the CCl4 + vehicle group

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