Fig. 3: CR8 decreases etoposide-induced cell death in primary neurons. | Cell Death & Disease

Fig. 3: CR8 decreases etoposide-induced cell death in primary neurons.

From: Comparing effects of CDK inhibition and E2F1/2 ablation on neuronal cell death pathways in vitro and after traumatic brain injury

Fig. 3

Neurons were treated with 50 μm of etoposide ± 10, 5, 1, 0.5, 0.25, and 0.125 μm CR8. Cell death, LDH release (a), and cell viability, Calcein signal (b), were measured 24 h after treatment. Histograms indicates LDH release and Calcein signal as percentage of control untreated RCN. n = 6/group for all groups. Data represent mean ± SEM of one-way ANOVA and Tukey post hoc analysis, *p < 0.05 vs. control, &p < 0.05 vs. etoposide + CR8

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