Fig. 8: CR8 reduces etoposide-induced caspase activation in primary neurons. | Cell Death & Disease

Fig. 8: CR8 reduces etoposide-induced caspase activation in primary neurons.

From: Comparing effects of CDK inhibition and E2F1/2 ablation on neuronal cell death pathways in vitro and after traumatic brain injury

Fig. 8

Neurons were treated with 50 μm of etoposide ± 1 μm CR8. Twenty-four hours later whole-cell lysates were fractioned on SDS-polyacrylamide gel and immunoblotted with antibodies against cleaved caspase-3, -αFodrin, and -Parp. Protein levels were quantified by densitometry, normalized to β-actin, and presented as fold change compared with control untreated levels. n = 3/group for all groups. Data represent mean ± SEM, * indicates significant difference from control, & indicates significant difference from CR8-treated neurons at the same time point, p < 0.05, via one-way ANOVA and Tukey post hoc test (b)

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