Fig. 6: Heparan sulfate and N-desulfated heparin suppress osteoclast formation in vivo. | Cell Death & Disease

Fig. 6: Heparan sulfate and N-desulfated heparin suppress osteoclast formation in vivo.

From: Suppressive effect of syndecan ectodomains and N-desulfated heparins on osteoclastogenesis via direct binding to macrophage-colony stimulating factor

Fig. 6: Heparan sulfate and N-desulfated heparin suppress osteoclast formation in vivo.

a Osteoclast formation. Histological sections of calvarial bone from mice injected with PBS (control), heparan sulfate, or N-desulfated heparin were stained with TRAP and the number of TRAP-positive osteoclasts [TRAP(+) OCs] was counted on the surface of the calvarial bone. Scale bar, 100 μm. b Calvarial bone marrow cavity. The extent of bone marrow cavity in H&E-stained calvarial bone sections was quantitatively analyzed to assess osteoclast bone resorption activity. Scale bar, 100 μm. Results represent the means ± SD (n = 4 as in a; n = 5 as in b). The p value indicates the comparison between the treatment group and control. *p < 0.05; **p < 0.01

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