Fig. 1: Expression of lncRNA AC003092.1 in GB cell lines and glioma tissues and its clinical significance. | Cell Death & Disease

Fig. 1: Expression of lncRNA AC003092.1 in GB cell lines and glioma tissues and its clinical significance.

From: Long noncoding RNA AC003092.1 promotes temozolomide chemosensitivity through miR-195/TFPI-2 signaling modulation in glioblastoma

Fig. 1

a Top five significantly up- and downregulated lncRNAs and mRNA expression of their nearby genes (distance < 300 kb) in U87TR cells. b lncRNA AC003092.1 expression level in TMZ-resistant and its parental GB cells, *P < 0.05 compared with U87 or U251 cells. c lncRNA AC003092.1 expression in primary and relapsed GB tissues was examined by qRT-PCR and normalized against U6 expression, *P < 0.05 compared with primary GB tissues. d Kaplan–Meier overall survival curves according to high and low lncRNA AC003092.1 expression, P < 0.0001. lncRNA AC003092.1 expression level was assessed by qRT-PCR, and the median value for all 75 GB cases was chosen as the cutoff point with which the cases were separated into high (n = 37) and low (n = 38) lncRNA AC003092.1 expression group. The patients were classified into two groups according to lncRNA AC003092.1 expression; Kaplan–Meier overall survival curves according to lncRNA AC003092.1 expression level, P < 0.0001. Data are presented as the mean ± SD of three independent experiments

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