Fig. 5: VEGFA and HMGA2 are both direct target genes of miR-1249. | Cell Death & Disease

Fig. 5: VEGFA and HMGA2 are both direct target genes of miR-1249.

From: P53-induced miR-1249 inhibits tumor growth, metastasis, and angiogenesis by targeting VEGFA and HMGA2

Fig. 5: VEGFA and HMGA2 are both direct target genes of miR-1249.The alternative text for this image may have been generated using AI.

a miR-1249 and its putative binding sequence in the wild-type (WT) and mutant (Mut) 3’-UTR of VEGFA or HMGA2. Overexpression of miR-1249 obviously decreased the luciferase activity that carried WT but not Mut 3′-UTR of VEGFA and HMGA2 in 293T and HCT116 cells. b, c Upregulation of miR-1249 could significantly decreased the expression of VEGFA and HMGA2 both on protein (b) and mRNA (c) levels in P53-/- and P53+/+ HCT116 cells. d Both VEGFA and HMGA2 mRNA were downregulated in xenografts tissues with high miR-1249. Data were presented as mean ± SD of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001

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