Fig. 8: miR-1249 downregulated VEGFA and HMGA2 expression, and inhibited Akt/mTOR signaling pathway and EMT process. | Cell Death & Disease

Fig. 8: miR-1249 downregulated VEGFA and HMGA2 expression, and inhibited Akt/mTOR signaling pathway and EMT process.

From: P53-induced miR-1249 inhibits tumor growth, metastasis, and angiogenesis by targeting VEGFA and HMGA2

Fig. 8: miR-1249 downregulated VEGFA and HMGA2 expression, and inhibited Akt/mTOR signaling pathway and EMT process.The alternative text for this image may have been generated using AI.

a The downregulation of VEGFA, p-VEGFR2, p-Akt and p-mTOR were countacted by VEGFA. b The downregulation of Vimentin and N-Cadherin and the upregulation fo E-Cadherin were countacted by both VEGFA and HMGA2. GAPDH was performed as a loading control. Data indicate mean ± SD of three independent experiments, *P < 0.05, **P < 0.01, P < 0.001

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