Fig. 5: In vitro hypoxia/reoxygenation of placental tissue leads to increased mitochondrial respiration and increased production of hydrogen peroxide during LEAK state respiration.
From: Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery
a Oxidative phosphorylation through mitochondrial complexes I + II (OXPHOS I + II), non-phosphorylating LEAK respiration, and maximum capacity of the respiratory system (ETS), were increased in healthy placental tissue after hypoxia/reoxygenation (p = 0.0065, p = 0.0091, p = 0.0060, fold change 1.401, 1.516, 1.527, respectively). Reserve capacity was not changed. b Hydrogen peroxide production was not changed during OXPHOS I + II, and was increased in LEAK respiration in healthy placental tissue after hypoxia/reoxygenation (p = 0.0020, fold change 1.945). N = 11; **P < 0.01
