Table 3 Gene sets enriched in ZEB1 HD class (A). Gene sets enriched in negative correlation with ZEB1 profile (B)

From: Loss of the candidate tumor suppressor ZEB1 (TCF8, ZFHX1A) in Sézary syndrome

	NAME	SIZE	ES	NES	NOM p-val	FDR q-val
(A)
1	HALLMARK_OXIDATIVE_PHOSPHORYLATION	188	0.67	2.67	0	0
2	HALLMARK_INTERFERON_ALPHA_RESPONSE	77	0.74	2.62	0	0
3	HALLMARK_INTERFERON_GAMMA_RESPONSE	171	0.65	2.58	0	0
4	HALLMARK_COMPLEMENT	181	0.58	2.31	0	0
5	HALLMARK_MYC_TARGETS_V1	171	0.57	2.29	0	0
6	HALLMARK_ADIPOGENESIS	169	0.53	2.08	0	0
7	HALLMARK_ALLOGRAFT_REJECTION	191	0.52	2.07	0	0
8	HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY	43	0.58	1.89	0	0.001
9	HALLMARK_APOPTOSIS	157	0.48	1.88	0	0.001
10	HALLMARK_IL6_JAK_STAT3_SIGNALING	85	0.51	1.85	0	0.001
11	HALLMARK_PROTEIN_SECRETION	88	0.5	1.83	0	0.001
12	HALLMARK_IL2_STAT5_SIGNALING	169	0.45	1.78	0	0.003
13	HALLMARK_MTORC1_SIGNALING	182	0.45	1.75	0	0.003
14	HALLMARK_FATTY_ACID_METABOLISM	140	0.45	1.73	0.001	0.004
15	HALLMARK_DNA_REPAIR	135	0.45	1.71	0.001	0.005
16	HALLMARK_KRAS_SIGNALING_UP	191	0.42	1.69	0	0.006
17	HALLMARK_XENOBIOTIC_METABOLISM	185	0.42	1.67	0.001	0.008
18	HALLMARK_INFLAMMATORY_RESPONSE	185	0.41	1.64	0	0.01
19	HALLMARK_HEME_METABOLISM	183	0.41	1.63	0.001	0.011
20	HALLMARK_TNFA_SIGNALING_VIA_NFKB	185	0.41	1.63	0.002	0.01
21	HALLMARK_G2M_CHECKPOINT	176	0.41	1.62	0.001	0.01
22	HALLMARK_UNFOLDED_PROTEIN_RESPONSE	104	0.42	1.55	0.011	0.018
23	HALLMARK_E2F_TARGETS	167	0.39	1.53	0.003	0.02
24	HALLMARK_COAGULATION	132	0.39	1.51	0.011	0.024
25	HALLMARK_CHOLESTEROL_HOMEOSTASIS	60	0.44	1.51	0.031	0.023
26	HALLMARK_PEROXISOME	94	0.4	1.45	0.041	0.04
27	HALLMARK_TGF_BETA_SIGNALING	49	0.43	1.45	0.043	0.041
28	HALLMARK_P53_PATHWAY	182	0.36	1.4	0.024	0.059
29	HALLMARK_ANDROGEN_RESPONSE	94	0.36	1.34	0.077	0.098
30	HALLMARK_UV_RESPONSE_UP	150	0.34	1.33	0.051	0.099
31	HALLMARK_ESTROGEN_RESPONSE_LATE	193	0.33	1.31	0.061	0.115
32	HALLMARK_PANCREAS_BETA_CELLS	36	0.42	1.3	0.129	0.114
(B)
1	HALLMARK_INTERFERON_ALPHA_RESPONSE	77	−0.57	−2.86	0	0
2	HALLMARK_INTERFERON_GAMMA_RESPONSE	171	−0.47	−2.68	0	0
3	HALLMARK_TNFA_SIGNALING_VIA_NFKB	185	−0.28	−1.65	0	0.029
4	HALLMARK_IL2_STAT5_SIGNALING	169	−0.28	−1.6	0	0.034
5	HALLMARK_APOPTOSIS	157	−0.28	−1.58	0	0.031
6	HALLMARK_DNA_REPAIR	135	−0.28	−1.56	0.008	0.029
7	HALLMARK_P53_PATHWAY	182	−0.25	−1.45	0.005	0.059
8	HALLMARK_ADIPOGENESIS	169	−0.24	−1.39	0.014	0.081
9	HALLMARK_OXIDATIVE_PHOSPHORYLATION	188	−0.24	−1.37	0.02	0.089
10	HALLMARK_UV_RESPONSE_UP	150	−0.23	−1.28	0.059	0.153
11	HALLMARK_COMPLEMENT	181	−0.21	−1.21	0.073	0.239

SIZE size of gene set, ES enriched score, NES normalized enriched score, NOM p-val nominal p-value, FDR q-val, false discovery rate q-value
Bold font denotes common gene sets enriched in both analyses

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Table 3 Gene sets enriched in ZEB1 HD class (A). Gene sets enriched in negative correlation with ZEB1 profile (B)

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