Fig. 5: Model of the FHC/miR-125b/p53 axis in NSCLC. | Cell Death & Disease

Fig. 5: Model of the FHC/miR-125b/p53 axis in NSCLC.

From: Ferritin heavy subunit enhances apoptosis of non-small cell lung cancer cells through modulation of miR-125b/p53 axis

Fig. 5

Over-expression of FHC (blue circle) leads to the repression of microRNA 125b. miR-125b inhibition promotes the translation of p53 (red circle) that, in turn, leads to the over-expression of pro-apoptotic protein BAX and the inhibition of the anti-apoptotic Bcl2. Consequently, disruption of the mitochondrial membrane potential (MMP) unleashes the enzymatic apoptotic machinery of caspases, and in particular caspase-9

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