Fig. 4: AIF2 KO does not affect mitochondrial morphology or respiratory activity. | Cell Death & Disease

Fig. 4: AIF2 KO does not affect mitochondrial morphology or respiratory activity.

From: Lack of the brain-specific isoform of apoptosis-inducing factor aggravates cerebral damage in a model of neonatal hypoxia–ischemia

Fig. 4: AIF2 KO does not affect mitochondrial morphology or respiratory activity.

a Representative photomicrographs in a cortical neuron show the morphology and number of mitochondria in WT and AIF2 KO mice at P9. There were no obvious differences between the two genotypes in terms of mitochondrial morphology (n = 2 for WT, n = 4 for AIF2 KO). b Mitochondrial respiratory activity in the WT and AIF2 KO mice at P9. There were no significant differences in the average values of respiratory activities or the respiratory control ratio (RCR). c The mtDNA copy number was not significantly different between WT and KO mouse pups under physiological conditions or at 24 h after HI (n = 6/group). d Immunoblotting of respiratory chain complexes I–V subunits in the mitochondrial fraction of WT and KO mice at P9 (n = 6/group). e Transcriptome results showed no significant changes in FPKM of mitochondrial fusion, fission, or biogenesis genes between the WT and KO group under physiological conditions. n = 6 for WT males, n = 6 for WT females, n = 8 for AIF2 KO males, and n = 8 for AIF2 KO females

Back to article page