Fig. 6: AIF2 KO has no effect on caspase-dependent and independent apoptosis. | Cell Death & Disease

Fig. 6: AIF2 KO has no effect on caspase-dependent and independent apoptosis.

From: Lack of the brain-specific isoform of apoptosis-inducing factor aggravates cerebral damage in a model of neonatal hypoxia–ischemia

Fig. 6: AIF2 KO has no effect on caspase-dependent and independent apoptosis.The alternative text for this image may have been generated using AI.

a Representative images show staining for the active form of caspase-3 at 6 and 24 h after HI. b Quantification of the number of active caspase-3-positive cells in WT and KO mice at 6 and 24 h post-HI. The bar graph has been divided into four sets for the cortex (CX), striatum (Str), CA1, and nuclei habenula (NH). There were no significant differences in the numbers of active caspase-3-positive cells. c Representative images showing the staining for the active form of AIF at 6 and 24 h after HI. d Quantification of the AIF-positive cells (nuclear AIF immunostaining) in WT and KO at 6 and 24 h post-HI. There were no significant differences between WT and KO at 6 h (n = 9/group) or 24 h (n = 8/group) after HI

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